White matter lesion burden mediates the relation between cerebrovascular risk
factors and frontal-subcortical cognitive functions in older adults. 
   Lead Investigator:    Bryant Duda
   Institution      :    Michigan Medicine, University of Michigan
   E-Mail           :    bryantdu@med.umich.edu
   Proposal ID      :    1397



   Proposal Description:
   Goals: Validate a stroke risk index as a predictor of reduced cognitive functions in older adults cross-validate this measure in a second sample, and assess group differences by race (African American and White) Assess white matter lesion burden as a mediator of cerebrovascular risk factors and cognitive performance.    We intend to test the stated hypotheses: the stroke risk index will significantly predict frontal-subcorticcal cognitive performance, this relation will be stronger in African Americans, and white matter hyperintensities will be identified as a mechanism of this relation.